There is strong demand for growth hormone and pharmaceutical applications expanded in last years. The substantial cost limits dramatically utilization of growth hormone. The primary reason for cost relates to complexity of recombinant DNA technology and inherited costs of this technology. One rabbit female can produce up to 10 liters of milk per year. Assuming that expected expression is about 1-10 g/l, a rabbit colony of few hundred animals can supply substantial amount of hormone. The scope of project involves creation of transgenic rabbits producing in mammary gland human growth hormone, achieving stability of hormone expression, high quality of hormone and availability in large quantities.

 

Mammary gland is considered as the best available bioreactor. Extensive studies have shown that it can serve as the source of a variety of complex recombinant proteins The transgene WAP:6xHishGH became stable integrated into the host genome, can be transmitted to the offspring and expressed. Mammary epithelial cells, which are the source of milk specific protein in the mammary gland, were confirmed to express the transgene.

 

There is strong demand for growth hormone and pharmaceutical applications expanded in last years. The substantial cost limits dramatically utilization of growth hormone.

 

The primary reason for cost relates to complexity of recombinant DNA technology and inherited costs of this technology. One rabbit female can produce up to 10 liters of milk per year.

 

Last minute info: Female rabbits producing growth hormone are available.